{"id":7642,"date":"2014-07-11T10:14:00","date_gmt":"2014-07-11T10:14:00","guid":{"rendered":"http:\/\/elza.magictrickshq.com\/?p=7642"},"modified":"2020-09-26T13:59:27","modified_gmt":"2020-09-26T13:59:27","slug":"cross-linking-only-works-when-sufficient-oxygen-is-present","status":"publish","type":"post","link":"https:\/\/www.staging.elza-institute.com\/pt\/cross-linking-only-works-when-sufficient-oxygen-is-present\/","title":{"rendered":"A reticula\u00e7\u00e3o s\u00f3 funciona quando existe oxig\u00e9nio suficiente"},"content":{"rendered":"

Ophthalmology Times.<\/h3>\n
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O sucesso do crosslinking corneano (CXL) para a doen\u00e7a ect\u00e1sica requer oxig\u00e9nio no tecido, e esta depend\u00eancia explica provavelmente a efici\u00eancia limitada dos protocolos de tratamento de alta intensidade (r\u00e1pido) e transepitelial, afirmou Farhad Hafezi, MD, PhD. Numa s\u00e9rie de estudos, o Dr. Hafezi e os seus colegas da Universidade de Genebra, na Su\u00ed\u00e7a, demonstraram que o efeito biomec\u00e2nico do CXL \u00e9 (a) dependente do oxig\u00e9nio e (b) diminui a efic\u00e1cia quando a intensidade \u00e9 aumentada e o tempo de tratamento reduzido, mesmo quando a dose total de energia (flu\u00eancia) permanece a mesma.<\/p>\n

\"Por defini\u00e7\u00e3o, o efeito de fortalecimento da c\u00f3rnea do tratamento com riboflavina e ultravioleta A (UVA) requer oxig\u00e9nio, porque resulta da reticula\u00e7\u00e3o do colag\u00e9nio e dos proteoglicanos, que \u00e9 mediada pela gera\u00e7\u00e3o de esp\u00e9cies reactivas de oxig\u00e9nio\", afirmou o Dr. Hafezi, professor e presidente do Departamento de Oftalmologia dos Hospitais da Universidade de Genebra, na Su\u00ed\u00e7a, e professor cl\u00ednico adjunto de oftalmologia da Keck School of Medicine da University of Southern California, em Los Angeles. \"Investiga\u00e7\u00f5es anteriores demonstraram que o oxig\u00e9nio na c\u00f3rnea se esgota rapidamente durante a irradia\u00e7\u00e3o CXL e a um ritmo mais r\u00e1pido quando se utilizam intensidades mais elevadas, o que suscita a preocupa\u00e7\u00e3o de que os protocolos de irradi\u00e2ncia elevada\/tempo de irradia\u00e7\u00e3o curto ou a presen\u00e7a de uma barreira epitelial intacta limitem a oportunidade de reposi\u00e7\u00e3o adequada de oxig\u00e9nio atrav\u00e9s da difus\u00e3o.<\/p>\n

Ler o artigo aqui<\/a><\/strong>.<\/h4>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

O sucesso do reticulado da c\u00f3rnea (CXL) para a doen\u00e7a ect\u00e1sica requer oxig\u00e9nio no tecido, e esta depend\u00eancia explica provavelmente a efici\u00eancia limitada dos protocolos de tratamento de alta intensidade (r\u00e1pido) e transepitelial, afirmou Farhad Hafezi, MD, PhD<\/p>","protected":false},"author":1,"featured_media":7776,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_angie_page":false,"page_builder":"","footnotes":""},"categories":[214,96],"tags":[130,100,109],"class_list":["post-7642","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-farhad-hafezi","category-popular-press","tag-cross-linking","tag-cxl","tag-pellucid-marginal-degeneration"],"acf":[],"yoast_head":"\nCross-Linking only works when sufficient oxygen is present - The ELZA Institute<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cross-Linking only works when sufficient oxygen is present - 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